Benzodiazepines are best when used early following a seizure starts, as a result of modifications at synapses that degrade GABA signaling in excess of time12,thirteenKeep an eye on Intently (2)diazepam will increase the stage or effect of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism.fentanyl intranasal and diazepa